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Tamoxifen
Written by NCI Thesaurus v.07.09d   
Definition of Tamoxifen
The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in dna synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, thereby inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma as well as in other cancers that express high levels of protein kinase C.

Tamoxifen is from the group

Protein Kinase C Inhibitor
Selective Estrogen Receptor Modulator

Other Names for Tamoxifen

Tamoxifen Citrate
(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate
(Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate
1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene Citrate
Apo-Tamox
Clonoxifen
Dignotamoxi
Ebefen
Emblon
Estroxyn
Fentamox
Gen-Tamoxifen
Genox
ICI 46,474
ICI-46474
Jenoxifen
Kessar
Ledertam
Lesporene
Nolgen
Noltam
Nolvadex
Nolvadex-D
Nourytam
Novo-Tamoxifen
Novofen
Noxitem
Oestrifen
Oncotam
PMS-Tamoxifen
Soltamox
TAM
TAMOXIFEN CITRATE
Tamax
Tamaxin
Tamifen
Tamizam
Tamofen
Tamoxasta
Tamoxifen citrate
Tamoxifeni Citras
Zemide

Source

NCI Thesaurus License

 
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