Physician Resources Home arrow Medical News arrow Pain appears common among patients with parkinsonís disease
Pain appears common among patients with parkinsonís disease
Written by Medical News Feed   

CHICAGO—Pain appears to be more common in individuals with Parkinson’s disease than in those without, suggesting that pain is associated with the condition, according to a report in the September issue of Archives of Neurology, one of the JAMA/Archives journals.

 Discuss this article on the forums. (0 posts)



“Patients with Parkinson’s disease often complain of painful sensations that may involve body parts affected and unaffected by dystonia,” or involuntary muscle contractions, the authors write as background information in the article. This pain may resemble cramping or arthritis, or have features of pain caused by nerve damage. “The high frequency of these pain disorders in the general population makes it hard to establish whether pain is more frequent among people with Parkinson’s disease than among age-matched controls.”

Giovanni Defazio, M.D., Ph.D., of the University of Bari, Italy, and colleagues compared 402 patients with Parkinson’s disease to 317 healthy individuals who were the same age. Participants provided information about their current age, the age at which they developed Parkinson’s disease, scores on disease rating scales and details regarding any pain that was present at the time of the study and lasted for at least three months.

Overall, pain was more common among Parkinson’s disease patients than among controls (281 or 69.9 percent vs. 199 or 62.8 percent). This was mainly attributable to dystonic pain, as rates of pain not associated with dystonia were similar among individuals with Parkinson’s disease (267 or 66.4 percent) and those without (199 or 62.8 percent).

“Nevertheless, we observed a significant association between Parkinson’s disease and non-dystonic pain, beginning after the onset of parkinsonian symptoms,” the authors write. “Cramping and central neuropathic [nervous system–related] pain were more frequent among Parkinson’s disease patients than controls. About one-quarter of patients who experienced pain reported pain onset before starting antiparkinsonian therapy.”

Basal ganglia, structures deep in the brain that control movement and are damaged in patients with Parkinson’s disease, also are involved with pain processing, the authors note. This might account for the increase in pain associated with Parkinson’s disease.

“These data support the hypothesis that pain begins at clinical onset of Parkinson’s disease or thereafter as a non-motor feature of Parkinson’s disease,” they conclude. “The findings of this study may have implications for designing studies aimed at understanding pain mechanisms in Parkinson’s disease and identifying specific treatment strategies.”
(Arch Neurol. 2008;65[9]:1191-1194. Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

For more information, contact JAMA/Archives media relations at 312/464-JAMA (5262) or e-mail mediarelations{at} .

 Discuss this article on the forums. (0 posts)

< Prev   Next >

Common Diseases

Swine Flu - Updates and information on H1N1 2009 (AKA Swine Influenza) pandemic.

Ankylosing spondylitis - Current protocols for diagnosis and treatment options.

Wegener granulomatosis - Autoimmune etiology and clinical course.

Diabetes - disease and management information, including diagnosis, typical treatment plans and diabetes supplies.


Medical Careers

The US medical jobs market has stayed hot for health care providers. Whether you believe that a provider shortage is in the offing or that the ratio of physicians-to-patients is too high, physician jobs and nursing jobs abound.

A wide variety of medical jobs can be found in the netdoc health care job listings. Particular strengths include permanent and locum tenens physician jobs, nursing jobs across the US, and radiology positions.

Other resources include physician salary information, medical career guidance, and the ability to post physician jobs.


When hiring your medical practice office manager, what was the most important consideration?
Copyright © 2005 - 2020 Medical Resource Group, LLC. All rights reserved.