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Physician Resources Home arrow Medical Dictionary arrow Voltage-Dependent Anion Channel-1
Voltage-Dependent Anion Channel-1
Written by NCI Thesaurus v.07.09d   
Definition of Voltage-Dependent Anion Channel-1
Expressed in heart, liver, and skeletal muscle by human VDAC1 Gene (Mitochondrial Porin Family), ubiquitous 282-aa 31-kDa Voltage-Dependent Anion Channel-1 protein consists mainly of membrane-spanning beta-sheets that form a channel in the mitochondrial outer membrane and plasma membrane that adopts transmembrane voltage-dependent open/closed conformations and allows diffusion of small hydrophilic molecules. In response to apoptotic signal transduction, BCL2 proteins regulate cell death by controlling mitochondrial membrane permeability during apoptosis -- BCLXL binds to and closes VDAC. Proapoptotic BAX and BAK accelerate VDAC opening, allowing cytochrome C to pass through VDAC, which activates death-driving proteolytic caspases. (NCI)

Voltage-Dependent Anion Channel-1 is from the group

Voltage-Dependant Anion Channel

Other Names for Voltage-Dependent Anion Channel-1

Voltage-Dependent Anion Channel-1
Outer Mitochondrial Membrane Protein Porin-1
Plasmalemmal Porin
Porin
Porin 31HL
Porin 31HM
VDAC-1
Voltage-Dependent Anion-Selective Channel Protein-1
hVDAC1

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