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Nimodipine
Written by NCI Thesaurus v.07.09d   
Definition of Nimodipine
A dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine inhibits the transmembrane influx of calcium ions in response to depolarization in smooth muscle cells, thereby inhibiting vascular smooth muscle contraction and inducing vasodilatation. Nimodipine has a greater effect on cerebral arteries than on peripheral smooth muscle cells and myocardial cells, probably because this agent can cross the blood brain barrier due to its lipophilic nature. Furthermore, this agent also inhibits the drug efflux pump P-glycoprotein, which is overexpressed in some multi-drug resistant tumors, and may improve the efficacy of some antineoplastic agents.

Nimodipine is from the group

Calcium Channel Blocker

Other Names for Nimodipine

Nimodipine
NIMO
NIMODIPINE
Nimotop
nimodipine

Source

NCI Thesaurus License

 
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