NR-LU-10 Antigen Written by NCI Thesaurus v.07.09d   

Definition of NR-LU-10 Antigen Ep-CAM (epithelial cell adhesion molecule) is a tumor-associated antigen, 40-kDa transmembrane glycoprotein, overexpressed in many solid tumors, including carcinomas of the lung, breast, ovary, colorectum, and squamous cell carcinoma of the head and neck. The role of Ep-CAM in carcinogenesis and malignant progression is unclear, but there is increasing evidence that it modulates cell-cell interactions and that its expression correlates with the rate of cell proliferation -- a promoting role of Ep-CAM in tissue invasion and metastasis has been suggested. The limited expression of Ep-CAM in normal epithelial tissues and immunogenic MHC class I and II restricted epitopes identified on Ep-CAM, provide opportunities for developing effective multiepitope cancer vaccines targeting Ep-CAM. NR-LU-10 is an IgG2b murine monoclonal antibody against Ep-CAM. NR-LU-10 Antigen is from the group Tumor Antigen Other Names for NR-LU-10 Antigen Ep-CAM 17-1A EGP-2 Epithelial Cell Adhesion Molecule GA733-2 NR-LU-10 Antigen NR-LU-10 antigen Source NCI Thesaurus License

 

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