MDM2 Protein
Written by NCI Thesaurus v.07.09d   
Definition of MDM2 Protein
Inhibits p53 trans-activation, cell cycle arrest, and apoptosis. MDM2 binds p53 in the cell cycle at S/G2M phase and targets p53 for proteasome-mediated proteolysis. MDM2 also inhibits Rb protein and binds p14(ARF), ribosomal protein L5, and specifically to RNA. MDM2 gene expression is induced by dna damage and regulated by the Ras-MAP kinase pathway. Some soft tissue sarcomas carry amplified MDM2 and overexpress MDM2 protein. (from SWISS-PROT Q00987, OMIM 164785, and NCI)

MDM2 Protein is from the group

Ligand Binding Protein

Other Names for MDM2 Protein

MDM2 Protein
Double Minute 2 Protein
MDM 2 Protein
Ubiquitin-Protein Ligase E3 MDM2
p53 Binding Protein
p53-Binding Protein MDM2


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