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Physician Resources Home arrow Medical Dictionary arrow Immunoglobulin Heavy Locus
Immunoglobulin Heavy Locus
Written by NCI Thesaurus v.07.09d   
Definition of Immunoglobulin Heavy Locus
This region represents the germline organization of the immunoglobulin heavy chain locus. The locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a D segment with a J segment -- a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. recombination of many different V segments with several D and J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink)

Immunoglobulin Heavy Locus is from the group

Immunoglobulin Family Gene

Other Names for Immunoglobulin Heavy Locus

Immunoglobulin Heavy Locus
IGH
Immunoglobulin Heavy Chain Gene
Immunoglobulin Heavy Chain Locus
Immunoglobulin Heavy Gene

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