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Maternal obesity prior to pregnancy associated with birth defects
Date: 2007/08/27 19:37 By: jbohm1 Status: User  
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This thread discusses the Content article: Maternal obesity prior to pregnancy associated with birth defects

Interesting association between obesity and birth defects. Any suggestions of the mechanism involved?
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Re:Maternal obesity prior to pregnancy associated with birth defects
Date: 2007/08/27 19:47 By: ohiomd Status: User  
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Obesity is associated with increased glucose levels which activate genes involved in its metabolism. Perhaps it is due to persistant gene activation of developmental genes that are in part regulated by glucose or one of its effectors.

Obesity has been shown to impact on a wide variety of cellular pathways involved in growth.
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