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Off-label use of drug-coated stents widespread and have high complication rates
Date: 2007/05/13 16:12 By: ohiomd Status: User  
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This thread discusses the Content article: Off-label use of drug-coated stents widespread and have high complication rates

Having been involved in clinical research and knowing how carefully clinical trials are regulated, I have wondered the merits of using products for unlabeled uses.
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Re:Off-label use of drug-coated stents widespread and have high complication rates
Date: 2007/05/13 16:15 By: wlw Status: User  
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I think an important consideration in using products in off-label uses is the differences between patient populations. I would guess that certain groups are much more vunerable to having complications because of their vunerability (children and the elderly).
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Re:Off-label use of drug-coated stents widespread and have high complication rates
Date: 2007/05/14 13:19 By: jbohm1 Status: User  
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I agree that certain populations are more vunerable but I also think that certain types of patients are more vunerable due to their underlying medical conditions. Another important factor is the experience of the healthcare professionals using the off-labeled stents. Studies have shown that the more a hospital uses a procedure, the less complications occur.
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Re:Off-label use of drug-coated stents widespread and have high complication rates
Date: 2007/05/14 13:22 By: toledo Status: User  
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Clinical trials have very careful inclusion/exclusion criteria. Are the same criteria used when applying an off-labeled use?
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