Topoisomerase Written by NCI Thesaurus v.07.09d   

Definition of Topoisomerase Enzymes that change the degree of supercoiling in DNA by cutting one or both strands. Type I topoisomerases cut only one strand of DNA -- type I topoisomerase of E. coli (omega protein) relaxes negatively supercoiled DNA and does not act on positively supercoiled DNA. Type II topoisomerases cut both strands of DNA -- type II topoisomerase of E. coli (DNA gyrase) increases the degree of negative supercoiling in DNA and requires ATP. It is inhibited by several antibiotics, including nalidixic acid and ovobiocin. Topoisomerase is from the group Isomerase Other Names for Topoisomerase Topoisomerase Source NCI Thesaurus License

 

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