Superantigen Written by NCI Thesaurus v.07.09d   

Definition of Superantigen Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions. Superantigen is from the group Toxin Other Names for Superantigen Superantigen Source NCI Thesaurus License

 

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