Methotrexate Written by NCI Thesaurus v.07.09d   

Definition of Methotrexate An antimetabolite with antineoplastic and immunomodulating properties. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant properties. (NCI04) Methotrexate is from the group Dihydro Folate Reductase Inhibitor Folate Antagonist Other Names for Methotrexate Methotrexate 4-Amino-10-methylfolic Acid 4-Amino-4-deoxy-10-methylpteroyl-L-glutamic Acid Abitrexate Alpha-Methopterin Amethopterin Brimexate CL 14377 CL-14377 Emtexate Emthexat Emthexate Farmitrexat Fauldexato Folex Folex PFS Lantarel Ledertrexate Lumexon METHOTREXATE MTX Maxtrex Medsatrexate Metex Methoblastin Methotrexate LPF Methotrexate Methylaminopterin Methotrexatum Metotrexato Metrotex Mexate Mexate-AQ N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid Novatrex Rheumatrex Texate Tremetex Trexeron Trixilem WR-19039 methotrexate Source NCI Thesaurus License

 

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