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Estramustine

Written by NCI Thesaurus v.07.09d

Definition of Estramustine

A synthetic molecule combining estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. (NCI04)

Estramustine is from the group

Nitrogen Mustard Compound
Tubulin Binding Agent

Other Names for Estramustine

Estramustine
17beta-(estra-1,3,5(10)-triene-3,17-diol 3-[bis(2-chloroethyl)carbamate]
ESTRAMUSTINE
Estradiol 3-[bis(2-chloroethyl)carbamate]
Leo 275
RO 21-8837
estra-1,3,5(10)triene-317beta-diol 3-[N,N-bis-(2-chloroethyl)carbamate]
Estradiol 3-bis(2-chloroethyl)carbamate
estramustine

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NCI Thesaurus License

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