| Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity -- however, the mechanism by which increased adiposity causes insulin resistance is unclear. Adipocytes secrete a unique signalling molecule, which was named resistin (for resistance to insulin). Circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. administration of anti-resistin antibody improves blood sugar and insulin action in mice with diet-induced obesity. Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action. Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment. Resistin is thus a hormone that potentially links obesity to diabetes. Diabetes Mellitus is from the group Endocrine Pancreas Disorder
Glucose Metabolism Disorder
Other Names for Diabetes Mellitus
Diabetes Mellitus
Diabetes
diabetes
diabetes mellitus
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