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Written by NetDoc.com Medical News Feed
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The skin’s ability to replace the tissue it sloughs off is controlled
by a variety of genes. However, a new study from Harvard Medical School
published in the May 4 issue of Cell, identifies a “master regulator” of
this regeneration process not only for skin, but for many epithelial tissues
including breast, prostate, and urogenital tract. This master regulator of
epithelial stem cells turns out to be the p63 gene, a close relative to the
well-known tumor-suppressing p53 gene. Without p63, mutant mice run out of
the regenerative epithelial stem cells. The findings also have implications
for cancers of the skin, breast and prostate, which are among the most
common human malignancies.
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