NetDoc - Hospital Ratings and Medical Jobs

User Quick Links

My shopping cart

Physician Resources Home

Medical Dictionary

Tegafur

Written by NCI Thesaurus v.07.09d

Definition of Tegafur

A congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme. Subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits dna synthesis and cell division by inhibiting thymidylate synthase and reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate. (NCI04)

Tegafur is from the group

Pyrimidine Antagonist
Thymidylate Synthase Inhibitor

Other Names for Tegafur

Tegafur
5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione
5-Fluoro-1-(tetrahydro-2-furanyl)-2,4-(1H,3H)-pyrimidinedione
5-Fluoro-1-(tetrahydro-2-furyl)-uracil
Citofur
Coparogin
Exonal
FT
FT-207
Fental
Florafur
Fluorofur
Ftorafur
Ftoral
Ftoralon
Fulaid
Fulfeel
Furafluor
Furofutran
Futraful
Lamar
Lifril
MJF-12264
N1-(2'-Furanidyl)-5-fluorouracil
Neberk
Nitobanil
Riol
Sinoflurol
Sunfural
Tefsiel
Uracil, 5-fluoro-1-(tetrahydro-2-furyl)-
Utefos
WR-220066
tegafur

Source

NCI Thesaurus License

Tag it:

< Prev		Next >

[ Back ]