| A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase -- MMPRs are also potent inhibitors of de novo purine synthesis. (NCI04) Mercaptopurine is from the group Immunosuppressant
Purine Antagonist
Other Names for Mercaptopurine
Mercaptopurine
1,7-Dihydro-6H-purine-6-thione
1,7-Dihydro-6H-purine-6-thione Monohydrate
3H-Purine-6-thiol
6 MP
6 Thiohypoxanthine
6 Thiopurine
6-MP
6-Mercaptopurine
6-Mercaptopurine Monohydrate
6-Purinethiol
6-Thiopurine
6-Thioxopurine
6H-Purine-6-thione, 1,7-dihydro- (9CI)
7-Mercapto-1,3,4,6-tetrazaindene
Alti-Mercaptopurine
Azathiopurine
BW 57-323H
Bw 57-323H
Flocofil
Ismipur
Leukerin
Leupurin
MERCAPTOPURINE
Mercaleukim
Mercaleukin
Mercaptina
Mercapto-6-purine
Mercaptopurinum
Mercapurin
Mern
NCI-C04886
NSC 755
Puri-Nethol
Purimethol
Purine, 6-mercapto-
Purine-6-thiol (8CI)
Purine-6-thiol Monohydrate
Purine-6-thiol, Monohydrate
Purine-6-thiol, monohydrate
Purinethiol
Purinethol
U-4748
WR-2785
mercaptopurine
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