Furosemide Written by NCI Thesaurus v.07.09d   

Definition of Furosemide An anthranilic derivative and loop diuretic with antihypertensive effect. Furosemide blocks the Na-K-Cl cotransporter (NKCC) in the luminal membrane of the thick ascending limb of the loop of henle in the kidney, by binding to the Cl-binding site located in the cotransporter's transmembrane domain, thereby inhibiting reabsorption of sodium, chloride, potassium ions and water. This agent reduces plasma and extracellular fluid volume resulting in decreased blood pressure and cardiac output. Furosemide is from the group Loop Diuretic Other Names for Furosemide Furosemide FRS FUROSEMIDE LB 502 LB-502 Lasix SK-Furosemide Source NCI Thesaurus License

 

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