Flutamide Written by NCI Thesaurus v.07.09d   

Definition of Flutamide A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (NCI04) Flutamide is from the group Anti-Androgen Aromatic Compounds Other Names for Flutamide Flutamide 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide 4'-Nitro-3'-trifluoromethylisobutyranilide Alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide Apimid Chimax Drogenil Euflex Eulexin Eulexine FLUT FLUTAMIDE Flucinom Flucinome Flugerel Fluken Flulem Fluta-Gry Flutabene Flutacan Flutamex Flutamin Flutan Flutaplex Fugerel Grisetin Niftolid Oncosal Profamid Prostacur Prostadirex Prostica Prostogenat SCH 13521 Sch 13521 Tafenil Tecnoflut Testotard flutamide Source NCI Thesaurus License

 

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