Fluorouracil Written by NCI Thesaurus v.07.09d   

Definition of Fluorouracil An antimetabolite and a fluoro-pyrimidine analog with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP) -- competing with uracil, F-UMP is incorporated into RNA, thereby inhibits rna synthesis and cell growth. Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), a necessary constituent of DNA. Other fluorouracil metabolites get incorporated into both RNA and DNA, thereby further hamper cellular growth. Fluorouracil is from the group Pyrimidine Antagonist Thymidylate Synthase Inhibitor Other Names for Fluorouracil Fluorouracil 2,4-Dioxo-5-fluoropyrimidine 5-FU 5-Fluoro-2,4(1H, 3H)-pyrimidinedione 5-Fluoro-2,4(1H,3H)-pyrimidinedione 5-Fluorouracil 5-Fluracil 5-Fu AccuSite Actino-Hermal Adrucil Arumel Cytosafe Efudex Efurix FLUOROURACIL Fiverocil Fluoro Uracil Fluoroplex Fluouracil Flurablastin Fluracedyl Fluracil Fluril Fluroblastin Flurox NSC 19893 NSC-19893 Ribofluor Ro 2-9757 Ro-2-9757 Timazin fluorouracil Source NCI Thesaurus License

 

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