Floxuridine Written by NCI Thesaurus v.07.09d   

Definition of Floxuridine A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of dna synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04) Floxuridine is from the group Pyrimidine Antagonist Other Names for Floxuridine Floxuridine 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil 2'-Deoxy-5-fluorouridine 2-Deoxy-5-fluorouridine 5-FUDR 5-FUdR 5-Fluoro-2'-deoxy-beta-uridine 5-Fluoro-2'-deoxyuridine 5-Fluorodeoxyuridine 5-Fluorouracil Deoxyriboside 5-Fluorouracil deoxyriboside 5-Fluorouridine Deoxyribose FDUR FLOXURIDINE FUDF FUDR FUdR Floxuridin Fluorodeoxyuridine Fluorouridine Deoxyribose Fluoruridine Deoxyribose Fluoruridine deoxyribose NSC 27640 NSC-27640 WR-138720 floxuridine Source NCI Thesaurus License

 

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