Etoposide Written by NCI Thesaurus v.07.09d   

Definition of Etoposide A semisynthetic derivative of podophyllotoxin, a substance extracted from the mandrake root podophyllum peltatum. Possessing potent antineoplastic properties, etoposide binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of dna replication and transcription, and apoptotic cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. (NCI04) Etoposide is from the group Epipodophyllotoxin Compound Other Names for Etoposide Etoposide 4'-Demethylepipodophyllotoxin 9-[4,6-O-ethylidene-beta-D-glucopyranoside 9-[(4,6-O-Ethylidene-beta-D-glucopyranosyl]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one Demethyl Epipodophyllotoxin Ethylidine Glucoside EPEG ETOPOSIDE Lastet NSC 141540 VP 16-213 VP-16 VP-16-213 Vepesid etoposide Source NCI Thesaurus License

 

< Prev		Next >

Common Diseases

Diabetes - disease and management information, including diagnosis, typical treatment plans and diabetes supplies.

Medical Careers

The US job market has stayed hot for health care providers. Whether you believe that a provider shortage is in the offing or that the ratio of physicians-to-patients is too high, physician jobs and nursing jobs abound.

A wide variety of medical jobs can be found in the netdoc health care job listings. Particular strengths include permanent and locum tenens physician jobs, nursing jobs across the US, and radiology positions.

Other resources include physician salary information, medical career guidance, and the ability to post physician jobs.

Medical Specialties

For specialty salary and job information, see medical specialty pages like cardiology, OB/Gyn,  and internal medicine specialty pages. Practice tools, like Psychiatry EMR and software for other specialties are available through individual specialty pages.

Medical dictionary