Epidermal Growth Factor Receptor Written by NCI Thesaurus v.07.09d   

Definition of Epidermal Growth Factor Receptor The epidermal growth factor receptor is a protein tyrosine kinase with two glycoprotein components of different molecular weight -- both contain phosphotyrosine and phosphothreonine but only the higher molecular weight form contains phosphoserine. The tyrosine kinase activity is required for internalization or degradation of EGF-EGFR receptor complexes. EGF stimulation of the receptor initiates DNA and protein synthesis in target cells. The receptor is not found on mitotically quiescent cells except the stomach where it controls synthesis and release of digestive enzymes and gastric acid. TGF alpha also binds to and activates the receptor. (from OMIM 131550 and NCI) Epidermal Growth Factor Receptor is from the group ErbB Receptor Family Protein Other Names for Epidermal Growth Factor Receptor Epidermal Growth Factor Receptor EGF Receptor EGFR ERBB Protein Epidermal Growth Factor Receptor Protein-Tyrosine Kinase ErbB1 HER1 Urogastrone Receptor c-erbB-1 Epidermal Growth Factor receptor erbB-1 proto-oncogene protein c-erbB-1 Source NCI Thesaurus License

 

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