| A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. (NCI04) Eflornithine is from the group Ornithine Decarboxylase Inhibitor
Other Names for Eflornithine
Eflornithine
2-(Difluoromethyl)-DL-ornithine
2-Difluoromethylornithine
Alpha-Difluoromethylornithine
D,L-alpha-Difluoromethylornithine
DFMO
Difluoromethylornithine
Difluromethylornithine
difluoromethylornithine
eflornithine
Source NCI Thesaurus License
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Medical Dictionary 
