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Echinomycin

Written by NCI Thesaurus v.07.09d

Definition of Echinomycin

A polypeptide quinoxaline antineoplastic antibiotic isolated from the bacterium streptomyces echinatus. Echinomycin intercalates into DNA at two locations simultaneously in a sequence-specific fashion, thereby inhibiting dna replication and RNA synthesis. (NCI04)

Echinomycin is from the group

DNA Minor Groove Binding Agent
Intercalating Agent
Miscellaneous Antineoplastic Antibiotic

Other Names for Echinomycin

Echinomycin
BRN 0078671
Bis-Quinoline Analogue
Echinomycin A
Levomycin
N,N'-(2,4,12,15,17,25-hexamethyl-11,24-bis(1-methylethyl)-27-(methylthio)-3,6,10,13,16,19,23,26-octaoxo-9,22-dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo(12.12.3)nonacosane-7,20-diyl)bis(2-quinoxalinecarboxamide)
Quinomycin A
SK 302B

Source

NCI Thesaurus License

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