Doxorubicin Written by NCI Thesaurus v.07.09d   

Definition of Doxorubicin An anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing dna replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during dna replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids -- the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects. Doxorubicin is from the group Doxorubicin Preparation Other Names for Doxorubicin Doxorubicin (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione 14-Hydroxydaunomycin DOXORUBICIN Hydroxyl Daunorubicin Hydroxyldaunorubicin doxorubicin Source NCI Thesaurus License

 

< Prev		Next >

Common Diseases

Diabetes - disease and management information, including diagnosis, typical treatment plans and diabetes supplies.

Medical Careers

The US medical jobs market has stayed hot for health care providers. Whether you believe that a provider shortage is in the offing or that the ratio of physicians-to-patients is too high, physician jobs and nursing jobs abound.

A wide variety of medical jobs can be found in the netdoc health care job listings. Particular strengths include permanent and locum tenens physician jobs, nursing jobs across the US, and radiology positions.

Other resources include physician salary information, medical career guidance, and the ability to post physician jobs.

Medical Specialties

For specialty salary and job information, see medical specialty pages like cardiology, OB/Gyn,  and internal medicine specialty pages. Practice tools, like Psychiatry EMR and software for other specialties are available through individual specialty pages.

Medical dictionary

Derived from one of the largest public databases of healthcare information, the netdoc medical dictionary has over 40,000 terms. A few examples

Meropenum (AKA Meropenem) is a broad spectrum carbapenem with antibacterial properties, synthetic meropenem inhibits cell wall synthesis in gram-positive and gram-negative bacteria...

Azaserine is a naturally occurring serine derivative diazo compound with antineoplastic properties...

Metformin is a biguanide with antihyperglycemic activity. Metformin hydrochloride exerts its action by improving hepatic sensitivity to insulin...