| An antibiotic isolated from streptomyces with potential antineoplastic activity. Diazooxonorleucine inhibits several glutamine-dependent biosynthetic pathways including the synthesis of D-glucosamine phosphate, purines and pyrimidines. As an L-glutamine antagonist, diazooxonorleucine inhibits phosphate-activated glutaminase, thereby interfering with glutamine metabolism, ultimately depleting cells of this essential amino acid and reducing the capacity to proliferate. Another mechanism of action including inhibition of glycoprotein, gamma-guanosine triphosphatase, DNA and rna synthesis has been proposed. Diazooxonorleucine is from the group Cytidine Triphosphate Synthetase Inhibitor
Miscellaneous Antineoplastic Antibiotic
Purine Antagonist
Other Names for Diazooxonorleucine
Diazooxonorleucine
6-DIAZO-5-OXO-L-NORLEUCINE
6-diazo-5-oxo-L-norleucine
6-diazo-5-oxo-norleucine
DON
NSC-7365
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