| A synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration. Dapsone is from the group Sulfone Anti-Infective Agent
Other Names for Dapsone
Dapsone
1358F
4,4'-Sulfonylbis[benzenamine]
4,4'-Sulfonylbisbenzamine
4,4'-Sulfonylbisbenzeneamine
4,4'-Sulfonyldianiline
Aczone
Avlosulfon
Bis(4-aminophenyl) sulfone
Bis(4-aminophenyl)sulfone
Croysulfone
DADPS
DAPSONE
DDS
Diphenasone
Disulone
Dumitone
Eporal
Novophone
Sulfona-MAE
Sulfona-Mae
Sulphadione
Undolac
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