Dactinomycin Written by NCI Thesaurus v.07.09d   

Definition of Dactinomycin A chromopeptide antineoplastic antibiotic isolated from the bacterium streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by rna polymerase -- it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. (NCI04) Dactinomycin is from the group Actinomycin Antibiotic Other Names for Dactinomycin Dactinomycin 2-bis[Cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3 ACTINOMYCIN D Actinomycin A IV Actinomycin C1 Actinomycin D Actinomycin I1 Actinomycin IV Actinomycin X 1 Actinomycin-[thr-val-pro-sar-meval] Cosmegen DACT DACTINOMYCIN Dactinomycine Lyovac Cosmegen Lyovac cosmegen Meractinomycin NSC-3053 dactinomycin Source NCI Thesaurus License

 

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