Cytochrome-P450-2C19 Written by NCI Thesaurus v.07.09d   

Definition of Cytochrome-P450-2C19 This protein is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. (from LocusLink) Cytochrome-P450-2C19 is from the group Cytochrome-P450 Other Names for Cytochrome-P450-2C19 Cytochrome P450, Family 2, Subfamily C, Polypeptide 19 CYP2C19 CYPIIC17 CYPIIC19 Cytochrome P450 2C19 Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 19 EC 1.14.14.1 Flavoprotein-Linked Monooxygenase Mephenytoin 4'-Hydroxylase Mephenytoin 4-Prime-Hydroxylase Microsomal Monooxygenase P450-11A P450-254C Xenobiotic Monooxygenase Source NCI Thesaurus License

 

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