| A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. (NCI04) Cyclosporine is from the group Immunosuppressant
Multidrug Resistance Modulator
Other Names for Cyclosporine
Cyclosporine
27-400
CYCLOSPORINE
Ciclosporin
CsA
Cyclosporin
Cyclosporin A
Neoral
OL 27-400
Sandimmun
Sandimmune
SangCya
cyclosporine
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