| A synthetic amino acid derivative of cyclopentanecarboxylic acid, Cycloleucine displays immunosuppressive, antineoplastic, and cytostatic properties. Believed to act in vivo as a valine antagonist and an NMDA receptor antagonist acting at the glycine site, Cycloleucine is a competitive inhibitor of many enzymes, such as methionine adenosyltransferase (S-adenosylmethionine biosynthesis). toxicity is correlated with a block of nucleic acid methylation -- cell cycle progression -- and DNA, RNA and protein biosynthesis. (NCI04) Cycloleucine is from the group Immunosuppressant
Other Names for Cycloleucine
Cycloleucine
1-Aminocyclopentane
1-Aminocyclopentanecarboxylic acid
1-aminocyclopentanecarboxylic acid
ACP
ACPC
CB 1639
CB-1639
NSC 1026
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