Cimetidine Written by NCI Thesaurus v.07.09d   

Definition of Cimetidine A histamine H(2)-receptor antagonist. Enhancing anti-tumor cell-mediated responses, cimetidine blocks histamine's ability to stimulate suppressor T lymphocyte activity and to inhibit natural killer (NK) cell activity and interleukin-2 production. Cimetidine also may inhibit tumor growth by suppressing histamine's growth-factor activity and blocking histamine-induced stimulation of vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor. (NCI04) Cimetidine is from the group Chemo Immunostimulant Adjuvant Endothelial Cell Inhibitor Other Names for Cimetidine Cimetidine N-Cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine Tagamet cimetidine Source NCI Thesaurus License

 

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