Cholera Toxin Written by NCI Thesaurus v.07.09d   

Definition of Cholera Toxin Secreted by Vibrio cholerae, Cholera toxin is a natural bacterial enterotoxin consisting of major components heavy A- and light B peptides (choleragenoid) that initiates a signaling cascade in intestinal epithelial cells causing a dysfunction of chloride channels, loss of water, and diarrhea. B peptide anchors the protein to epithelia -- A peptide enters the cytoplasm and activates adenylate cyclase. Due to its cytotoxicity, cholera toxin is being studied for tumor cell targeting and cancer chemotherapy. (NCI04) Cholera Toxin is from the group Bacterial Toxin Enterotoxin Other Names for Cholera Toxin Cholera Toxin Source NCI Thesaurus License

 

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