| An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including dna repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04) Carmustine is from the group DNA Adduct Forming Agent
Nitrosourea Compound
Other Names for Carmustine
Carmustine
1,3-Bis(2-chloroethyl)-1-nitrosourea
1,3-Bis(beta-chloroethyl)-1-nitrosourea
BCNU
Becenum
Becenun
BiCNU
Bis(chloroethyl) Nitrosourea
Bis-Chloronitrosourea
CARMUSTINE
Carmubris
Carmustin
Carmustinum
FDA 0345
Gliadel
N,N'-Bis(2-chloroethyl)-N-nitrosourea
N,N'-bis(2-chloroethyl)-N-nitrosourea
NSC 409962
Nitrourean
Nitrumon
SK 27702
SRI 1720
WR-139021
carmustine
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