| A zinc-dependent enzyme isolated from a strain of the bacterium Pseudomonas. Because glucarpidase rapidly hydrolyzes methotrexate into inactive metabolites, it may be useful as a rescue agent for methotrexate-induced nephrotoxicity. In antibody-directed enzyme prodrug therapy (ADEPT), this agent is conjugated with an antibody that binds to a specific tumor cell type, allowing for glucarpidase-catalyzed activation of a co-administered prodrug at the site of the tumor. Carboxypeptidase-G2 is from the group Nephroprotective Agent
Other Names for Carboxypeptidase-G2
Glucarpidase
CPDG2
Carboxypeptidase G2
Voraxaze
carboxypeptidase-G2
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