| An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the dna replication machinery. (NCI) Camptothecin is from the group Topoisomerase-I Inhibitor
Other Names for Camptothecin
Camptothecin
(+)-Camptothecin
(S)-4-ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolozino[1,2-b]quinoline-3,14(4H,12H)-dione
1H-Pyrano[3',3'.6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4hydroxy-(S)-(9CI)
20(S)-Camptothecine
20-(S)-camptothecine
21, 22-Secocamptothecin-21-oic acid lactone
21, 22-secocamptothecin-21-oic acid lactone
camptothecin
camptothecine
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