BRCA1 Protein Written by NCI Thesaurus v.07.09d   

Definition of BRCA1 Protein BRCA1, which functions as a tumor suppressor in human breast cancer cells, is a nuclear phosphoprotein which associates with rna polymerase II holoenzyme. Mutations in BRCA1 are predicted to be responsible for approximately 45% of inherited breast cancer and more than 80% of inherited breast and ovarian cancer. BRCA1 may function as a transcriptional regulator, due to an amino terminal DNA-binding ring finger motif, nuclear localization signals, and an acidic carboxy terminal domain. BRCA1 is also a granin-like protein that functions as a secreted growth inhibitory protein. BRCA1 may normally serve as a negative regulator of mammary epithelial cell growth. This function is compromised in breast cancer either by direct mutation or by alterations in gene expression. BRCA1 participates in transcription-coupled repair of oxidative DNA damage. (LocusLink) BRCA1 Protein is from the group Regulatory Protein Other Names for BRCA1 Protein BRCA1 Protein BRCA1 Breast Cancer 1, Early Onset Protein Breast Cancer Type 1 Susceptibility Protein Breast-Ovarian Cancer Protein Source NCI Thesaurus License

 

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