Admin

Azathioprine
Written by NCI Thesaurus v.07.09d   
Definition of Azathioprine
A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.

Azathioprine is from the group

Immunosuppressant
Purine Antagonist

Other Names for Azathioprine

Azathioprine
6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine
AZA
AZATHIOPRINE
AZTP

Source

NCI Thesaurus License

 

 
Next >

Medical Careers

The US medical jobs market has stayed hot for health care providers. Whether you believe that a provider shortage is in the offing or that the ratio of physicians-to-patients is too high, physician jobs and nursing jobs abound.

A wide variety of medical jobs can be found in the netdoc health care job listings. Particular strengths include permanent and locum tenens physician jobs, nursing jobs across the US, and radiology positions.

Other resources include physician salary information, medical career guidance, and the ability to post physician jobs.

Polls

How much of your CME do you do online?
 
Copyright © 2005 - 2010 Medical Resource Group, LLC. All rights reserved.