Written by NCI Thesaurus v.07.09d
|
|
Definition of Azathioprine
| A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.
Azathioprine is from the group
Immunosuppressant
Purine Antagonist
Other Names for Azathioprine
Azathioprine
6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine
AZA
AZATHIOPRINE
AZTP
Source
NCI Thesaurus License
|
|
|
|
NetDoc Physician Specialty Pages
Medical Careers
The US medical jobs market has stayed hot for health care providers. Whether you believe
that a provider shortage is in the offing or that the ratio of physicians-to-patients
is too high, physician
jobs and nursing jobs abound.
A wide variety of medical jobs can be found in the netdoc health care job listings. Particular strengths include permanent and locum tenens physician jobs, nursing jobs across the US, and radiology positions.
Other resources include physician salary information, medical career guidance, and the ability to post physician jobs.