Written by NCI Thesaurus v.07.09d
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Definition of Asparaginase | An enzyme isolated from the bacterium Escherichia coli. asparagine is critical to protein synthesis in leukemic cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting leukemic cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle. This agent also induces apoptosis in tumor cells. The Colaspase term refers to the asparaginase that is derived form selected strains of E. Coli. Asparaginase is from the group Unclassified Chemotherapy Agent
Other Names for Asparaginase
Asparaginase
ASP-1
ASPARAGINASE
Asparaginase II
Asparaginase-E.Coli
Colaspase
EC 3.5.1.1
Elspar
Kidrolase
L-ASP
L-Asnase
L-Asparaginase
L-Asparagine Amidohydrolase
L-Asparagine amidohydrolase
Laspar
Lcf-ASP
Leucogen
Leunase
MK-965
Paronal
Re-82-TAD-15
Serasa
asparaginase
Source NCI Thesaurus License
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