Written by NCI Thesaurus v.07.09d
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Definition of Asparaginase | An enzyme isolated from the bacterium Escherichia coli. asparagine is critical to protein synthesis in leukemic cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting leukemic cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle. This agent also induces apoptosis in tumor cells. The Colaspase term refers to the asparaginase that is derived form selected strains of E. Coli. Asparaginase is from the group Unclassified Chemotherapy Agent
Other Names for Asparaginase Asparaginase ASP-1 ASPARAGINASE Asparaginase II Asparaginase-E.Coli Colaspase EC 3.5.1.1 Elspar Kidrolase L-ASP L-Asnase L-Asparaginase L-Asparagine Amidohydrolase L-Asparagine amidohydrolase Laspar Lcf-ASP Leucogen Leunase MK-965 Paronal Re-82-TAD-15 Serasa asparaginase
Source NCI Thesaurus License
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