| An amino-acridine derivative with antineoplastic activity. Amsacrine intercalates DNA, thereby causing double-strand breaks in DNA and preventing dna synthesis and repair. DNA-intercalating also interferes with topoisomerase II activity, thereby terminating dna replication and leading to S phase and G2 arrest. Furthermore, amsacrine induces transcription of tumor promoter p53 protein in addition to blocking p53 ubiquitination, thereby induces p53-dependent apoptosis of tumor cells. Amsacrine is from the group Acridine
Topoisomerase-II Inhibitor
Other Names for Amsacrine
Amsacrine
4'-(9-Acridinylamino)methane-sulfon-m-anisidide
AMSA
Acridinyl Anisidide
Amekrin
Amsa P-D
Amsidine
Amsidyl
CI-880
Cain's Acridine
Lamasine
N-[4-(9-Acridinylamino)-3-methoxyphenyl]methanesulfonamide
SN 11841
SN-11841
amsacrine
m-AMSA
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