| A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04) Aminopterin is from the group Dihydro Folate Reductase Inhibitor
Folate Antagonist
Other Names for Aminopterin
Aminopterin
4-Aminofolic Acid
4-Aminofolic acid
4-Aminopteroylglutamic Acid
4-Aminopteroylglutamic acid
APGA
Aminopterin Sodium
Aminopteroylglutamic Acid
aminopterin
Source NCI Thesaurus License
|
Medical Dictionary 
