| The trihydrate form of a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues. Amifostine is from the group Cytoprotective Agent
Other Names for Amifostine
Amifostine Trihydrate
2-[(3-Aminopropyl)amino]ethanethiol Dihydrogen Phosphate Ester
APAETP
Amifostine
Aminopropylaminoethylthiophosphoric Acid
Ethiofos
Ethyol
Gammaphos
S-(N-(3-Aminopropyl)-2-aminoethyl)thiophosphoric Acid
S-2-(3-Aminopropylamino)ethylphosphorothioic Acid
WR 2721
WR-2721
WR2721
YM-08310
amifostine
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