Adenine Nucleotide Translocator-1 Written by NCI Thesaurus v.07.09d   

Definition of Adenine Nucleotide Translocator-1 Expressed in heart, kidney, liver, skeletal muscle by human SLC25A4 Gene (Mitochondrial Carrier Family), 298-aa 33-kDa homodimeric adenine Nucleotide Translocator-1 is an integral membrane protein embedded asymmetrically in the inner mitochondrial membrane that catalyzes transmembrane exchange of ADP and ATP and determines the rate of ADP/ATP flux between mitochondrion and cytosol. Strongly similar to murine Ant1, ANT1 contains 3 solute carrier (Solcar) repeats and the signature RRRMMM motif of nucleotide carriers -- six alpha helices form a compact transmembrane domain. Defects in SLC25A4 are a cause of PEO. Adenine Nucleotide Translocator-1 is from the group Adenosine Nucleotide Transporter Other Names for Adenine Nucleotide Translocator-1 Adenine Nucleotide Translocator-1 ADP-ATP Translocase-1 ANT ANT1 Heart-Skeletal Muscle ADP-ATP Carrier Protein-T1 Mitochondrial Adenine Nucleotide Translocator Solute Carrier Family 25 Member-4 Skeletal Muscle Adenine Nucleotide Translocator-1 T1 Source NCI Thesaurus License

 

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